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KMID : 0043319930160010006
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Archives of Pharmacal Research
1993 Volume.16 No. 1 p.6 ~ p.12
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The Effects of KR-10876, a New Quinolone Antimicrobial Agents, on the Central Nervous System
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Kim EJ
Cha SW/Shin HS/Roh JK/Park MW/Kim WJ
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Abstract
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To evaluate KR-10876, a new fluoroquinolone antibacterial agent, its effects on the central nervous system (CNS) were investigated in mice as part of pharmacological study, and the results were compared with those for ciprofloxacin and ofloxacin, two prototypes of quinolone antibacterial agents. All the parameters indicative of CNS function and acute toxicity were measured by close observation of the animals at regular time intervals after oral treatment of test compounds. KR-10876, ciprofloxacin and ofloxacin exerted a dose-dependent effect on the CNS functions studied. KR-10876 did not have any effects on the parameters measured at lower dose (100, 300mg/kg, p.o.), but at high dose (1,000mg/kg, p.o.), it caused ptosis, suppressed spontaneous locomotor activity, hypothermia, and prolonged hexobarbital-induced sleeping time. KR-10876 also had a slight effect on motor coordination only at high dose. Similar to ciprofloxacin and ofloxacin, KR-10876 did not protect mice from pentylenetetrazol-, strychnine-, and electroshock-induced convulsions at doses tested. These findings demonstrate that KR-10876 affects CNS functions only at high doses. The rank order for effects is ofloxacin > or = KR-10876 > ciprofloxacin.
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KEYWORD
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